GGTI-2418
Cat. No.：YN481535
CAS No. ：501010-06-6
规格
价格(RMB)
库存
| 产品名称: | GGTI-2418 |
| CAS No.: | 501010-06-6 |
| Chemical Name: | N-[[(2S)-4-[(4-methyl-1H-imidazol-5-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-L-leucine |
| Synonyms: | L-Leucine,N-[[(2S)-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-;(2S)-2-[[(2S)-2-benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxopiperazine-1-carbonyl]amino]-4-methylpentanoic acid;GGTI-2418;M67G28K74K;(S)-2-((S)- |
| 分子量: | 441.52 |
| 分子式: | C₂₃H₃₁N₅O₄ |
| SMILES: | CC(C)C[C@@H](C(O)=O)NC(N1[C@@H](CC2=CC=CC=C2)C(N(CC3=C(C)N=CN3)CC1)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GGTI-2418 是一种高效，竞争性和选择性的香叶基香叶基转移酶 I (GGTase I) 抑制剂。GGTI-2418 抑制GGTase I和 FTase 活性，IC50分别为 9.5 nM 和 53 μM。GGTI-2418 还增强 p27(Kip1) 并诱导乳腺肿瘤显着消退。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kazi, A., Carie, A., Blaskovich, M.A., et al.Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: Implications for breast cancer therapyMol. Cell Biol.29(8),2254-2263(2009)
