Linerixibat
Cat. No.：YN481548
CAS No. ：1345982-69-5
规格
价格(RMB)
库存
| 产品名称: | Linerixibat |
| CAS No.: | 1345982-69-5 |
| Chemical Name: | 3-[[[(3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl]methyl]amino]-pentanedioic acid |
| Synonyms: | GSK2330672 |
| 分子量: | 546.68 |
| 分子式: | C₂₈H₃₈N₂O₇S |
| SMILES: | O=C(O)CC(NCC1=C(OC)C=C(C2=C1)[C@@H](C3=CC=CC=C3)N[C@](CC)(CCCC)CS2(=O)=O)CC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Linerixibat (GSK2330672) 是一种高效，不可吸收且具有口服活性的顶端钠依赖性胆汁酸转运蛋白 (ASBT) 抑制剂，对人ASBT的IC50为 42 nM。Linerixibat 可用作降脂剂，具有研究 2 型糖尿病和原发性胆源性胆管炎的潜力。 |
| IC50和靶点: | |
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Wu, Y., Aquino, C.J., Cowan, D.J., et al.Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetesJ. Med. Chem.56(12),5094-5114(2013)
