HLM006474
Cat. No.：YN481550
CAS No. ：353519-63-8
规格
价格(RMB)
库存
| 产品名称: | HLM006474 |
| CAS No.: | 353519-63-8 |
| Chemical Name: | 7-[(4-ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol |
| Synonyms: | HLM006474; HLM-006474; HLM 006474; |
| 分子量: | 399.48 |
| 分子式: | C₂₅H₂₅N₃O₂ |
| SMILES: | OC(C1=NC(C)=CC=C1C=C2)=C2C(NC3=NC=CC=C3)C(C=C4C)=CC=C4OCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HLM006474 是一种光谱的E2F抑制剂，在 A375 细胞中，可抑制 E2F4 DAN 结合，IC50值为 29.8 µM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ma, Y., Kurtyaka, C.A., Boyapalle, S., et al.A small-molecule E2F inhibitor blocks growth in a melanoma culture modelCancer Res.68(15),6292-6299(2008)
Kurtyaka, C.A., Chen, L., and Cress, W.D.E2F inhibition synergizes with paclitaxel in lung cancer cell linesPLoS One9(5),e96357(2014)
Sangwan, M., McCurdy, S.R., Livne-Bar, I., et al.Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiationOncogene31(48),5019-5028(2012)
Rouaud, F., Hamouda-Tekaya, N., Cerezo, M., et al.E2F1 inhibition mediates cell death of metastatic melanomaCell Death Dis.9(5),527(2018)
