ISO-1
Cat. No.：YN481552
CAS No. ：478336-92-4
规格
价格(RMB)
库存
| 产品名称: | ISO-1 |
| CAS No.: | 478336-92-4 |
| Chemical Name: | 4,5-dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid, methyl ester |
| Synonyms: | MIF Antagonist |
| 分子量: | 235.24 |
| 分子式: | C₁₂H₁₃NO₄ |
| SMILES: | O=C(OC)CC1ON=C(C(C=C2)=CC=C2O)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ISO-1 是巨噬细胞移动抑制因子(MIF) 拮抗剂，IC50值为 7 μM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Xu, L., Li, Y., Sun, H., et al.Current developments of macrophage migration inhibitory factor (MIF) inhibitorsDrug Discov. Today18(11-12),592-600(2013)
Lubetsky, J.B., Dios, A., Han, J., et al.The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agentsJ. Biol. Chem.277(28),24976-24982(2002)
Al-Abed, Y., Dabideen, D., Aljabari, B., et al.ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsisJ. Biol. Chem.280(44),36541-36544(2005)
Dagia, N.M., Kamath, D.V., Bhatt, P., et al.A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitisEur. J. Pharmacol.607(1-3),201-212(2009)
Chen, P.F., Luo, Y.l., Wang, W., et al.ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthmaMol. Med.16(9-10),400-408(2010)
