LDN-27219
Cat. No.：YN481553
CAS No. ：312946-37-5
规格
价格(RMB)
库存
| 产品名称: | LDN-27219 |
| CAS No.: | 312946-37-5 |
| Chemical Name: | 2-[(3,4-dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-acetic acid, hydrazide (ACl) |
| Synonyms: | LDN 27219;LDN 27219 |
| 分子量: | 408.50 |
| 分子式: | C₂₀H₁₆N₄O₂S₂ |
| SMILES: | O=C1N(C2=CC=CC=C2)C(SCC(NN)=O)=NC3=C1C(C4=CC=CC=C4)=CS3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LDN-27219是人组织型转谷氨酰胺酶（hTGase）抑制剂，IC50为600nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Duval, E., Case, A., Stein, R.L., et al.Structure-activity relationship study of novel tissue transglutaminase inhibitorsBioorg. Med. Chem. Lett.15(7),1885-1889(2005)
Case, A., and Stein, R.L.Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitorBiochemistry46(4),1106-1115(2007)
Pinilla, E., Comerma-Steffensen, S., Prat-Duran, J., et al.Transglutaminase 2 inhibitor LDN 27219 age-dependently lowers blood pressure and improves endothelium-dependent vasodilation in resistance arteriesHypertension77(1),216-227(2021)
