Avoralstat
Cat. No.：YN481560
CAS No. ：918407-35-9
规格
价格(RMB)
库存
| 产品名称: | Avoralstat |
| CAS No.: | 918407-35-9 |
| Chemical Name: | 3-[2-[[[4-(aminoiminomethyl)phenyl]amino]carbonyl]-4-ethenyl-5-methoxyphenyl]-6-[[(cyclopropylmethyl)amino]carbonyl]-2-pyridinecarboxylic acid |
| Synonyms: | BCX4161 |
| 分子量: | 513.54 |
| 分子式: | C₂₈H₂₇N₅O₅ |
| SMILES: | O=C(C1=NC(C(NCC2CC2)=O)=CC=C1C3=CC(OC)=C(C=C)C=C3C(NC4=CC=C(C(N)=N)C=C4)=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Avoralstat (BCX4161) 是一种有效的，具有口服活性的血浆激肽释放酶(PKK)抑制剂，用于研究遗传性血管性水肿。 |
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Cornpropst, M., Collis, P., Collier, J., et al.Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: Phase 1 studyAllergy71(12),1676-1683(2016)
Sun, Y.J., Velez, G., Parsons, D.E., et al.Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in miceJ. Clin. Invest.131(10),e147973(2021)
Hu, X., Shrimp, J.H., Guo, H., et al.Discovery of TMPRSS2 inhibitors from virtual screening as a potential treatment of COVID-19ACS Pharmacol. Transl. Sci.4(3),1124-1135(2021)
