Ibiglustat
Cat. No.：YN481561
CAS No. ：1401090-53-6
规格
价格(RMB)
库存
| 产品名称: | Ibiglustat |
| CAS No.: | 1401090-53-6 |
| Chemical Name: | N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]-carbamic acid, (3S)-1-azabicyclo[2.2.2]oct-3-yl ester |
| Synonyms: | Venglustat; SAR402671; GZ402671 |
| 分子量: | 389.49 |
| 分子式: | C₂₀H₂₄FN₃O₂S |
| SMILES: | O=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ibiglustat (Venglustat) 是选择性的、葡糖神经酰胺合成酶(GCS)的变构抑制剂，能通过血脑屏障。可用于帕金森病、法布里病和戈谢病的研究。 |
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Ashe, K.M., Budman, E., Bangari, D.S., et al.Efficacy of enzyme and substrate reduction therapy with a novel antagonist of glucosylceramide synthase for Fabry diseaseMol. Med.21(1),389-399(2015)
Marshall, J., Sun, Y., Bangari, D.S., et al.CNS-accessible inhibitor of glucosylceramide synthase for substrate reduction therapy of neuronopathic Gaucher diseaseMol. Ther.24(6),1019-1029(2016)
