L-Alanosine
Cat. No.：YN481567
CAS No. ：5854-93-3
规格
价格(RMB)
库存
| 产品名称: | L-Alanosine |
| CAS No.: | 5854-93-3 |
| Chemical Name: | 3-(hydroxynitrosoamino)-L-alanine |
| Synonyms: | 丙氨菌素; NSC-153353 |
| 分子量: | 149.11 |
| 分子式: | C₃H₇N₃O₄ |
| SMILES: | N[C@@H](CN(O)N=O)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-Alanosine (NSC-153353) 是来自Streptomyces alanosinicus的抗生素，具有抗肿瘤和抗病毒活性。L-Alanosine (NSC-153353) 抑制腺苷酸琥珀酸合成酶，将肌苷一磷酸 (IMP) 转化为腺苷酸琥珀酸。L-Alanosine (NSC-153353) 阻断常见的从头嘌呤生物合成途径，从而抑制具有 MTAP 缺陷的肿瘤细胞。 |
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Batova, A., Diccianni, M.B., Omura-Minamisawa, M., et al.Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitroCancer Res.59(7),1492-1497(1999)
Karikari, C.A., Mullendore, M., Esheleman, J.R., et al.Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancersMol. Cancer Ther.4(12),1860-1866(2005)
Gale, G.R., Ostrander, W.E., and Atkins, L.M.Effects of alanosine on purine and pyrimidine synthesisBiochem. Pharmacol.19(9),1823-1832(1968)
Li, C.-F., Fang, F.-M., Kung, H.-J., et al.Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevanceOncotarget5(22),11428-11441(2014)
Kindler, H.L., Burris, H.A., III, Sandler, A.B., et al.A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancerInvest New Drugs27(1),75-81(2009)
