Miglustat hydrochloride
Cat. No.：YN481577
CAS No. ：210110-90-0
规格
价格(RMB)
库存
| 产品名称: | Miglustat hydrochloride |
| CAS No.: | 210110-90-0 |
| Chemical Name: | 1-butyl-2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, monohydrochloride |
| Synonyms: | N-Butyldeoxynojirimycin, Hydrochloride; NB-DNJ hydrochloride; OGT918 hydrochloride |
| 分子量: | 255.74 |
| 分子式: | C₁₀H₂₂ClNO₄ |
| SMILES: | O[C@H]1[C@H](O)[C@@H](CO)N(CCCC)C[C@@H]1O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Miglustat hydrochloride 是一种葡萄糖神经酰胺合成酶抑制剂，可作用于 I 型戈谢病。 |
| IC50和靶点: | |
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Lee, J.C., Francis, S., Dutta, D., et al.Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidasesJ. Org. Chem.77(7),3082-3098(2012)
Alfonso, P., Pampín, S., Estrada, J., et al.Miglustat (NB-DNJ) works as a chaperone for mutated acid β-glucosidase in cells transfected with several Gaucher disease mutationsBlood Cells Mol. Dis.35(2),268-276(2005)
Pollock, S., Dwek, R.A., Burton, D.R., et al.N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome deliveryAIDS22(15),1961-1969(2008)
