Gimeracil
Cat. No.：YN481587
CAS No. ：103766-25-2
规格
价格(RMB)
库存
| 产品名称: | Gimeracil |
| CAS No.: | 103766-25-2 |
| Chemical Name: | 5-chloro-4-hydroxy-2(1H)-pyridinone |
| Synonyms: | 吉美嘧啶; Gimestat |
| 分子量: | 145.54 |
| 分子式: | C₅H₄ClNO₂ |
| SMILES: | O=C1C=C(O)C(Cl)=CN1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gimeracil 是口服氟嘧啶衍生物 S-1 的成分，抑制 DNA DSB 的修复，是DPYD(二氢嘧啶脱氢酶，DPD) 的有效抑制剂。 |
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Tatsumi, K., Fukushima, M., Shirasaka, T., et al.Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extractsJpn. J. Cancer Res.78(7),748-755(1987)
Sakata, K.I., Someya, M., Matsumoto, Y., et al.Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombinationCancer Sci.102(9),1712-1716(2011)
