Ezutromid
Cat. No.：YN481610
CAS No. ：945531-77-1
规格
价格(RMB)
库存
| 产品名称: | Ezutromid |
| CAS No.: | 945531-77-1 |
| Chemical Name: | 5-(ethylsulfonyl)-2-(2-naphthalenyl)-benzoxazole |
| Synonyms: | SMT C1100; BMN 195; VOX-C1100 |
| 分子量: | 337.39 |
| 分子式: | C₁₉H₁₅NO₃S |
| SMILES: | O=S(C1=CC=C(OC(C2=CC=C3C=CC=CC3=C2)=N4)C4=C1)(CC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ezutromid (SMT C1100) 是一种首创的，具有口服活性的苯并恶唑utrophin调节剂，EC50为 0.91 μM。Ezutromid 可用于 Duchenne 型肌营养不良症 (DMD) 的研究。Ezutromid 抑制人肝微粒体 CYP1A2 酶活性，IC50为 5.4 μM。 |
| IC50和靶点: | |
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Tinsley, J.M., Fairclough, R.J., Storer, R., et al.Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mousePLoS One6(5),e19189(2011)
Chancellor, D.R., Davies, K.E., De Moor, O., et al.Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophyJ. Med. Chem.54(9),3241-3250(2011)
Chatzopoulou, M., Claridge, T.D.W., Davies, K.E., et al.Isolation, structural identification, synthesis, and pharmacological profiling of 1,2- trans-dihydro-1,2-diol metabolites of the utrophin modulator ezutromidJ. Med. Chem.63(5),2547-2556(2020)
