BVT 2733
Cat. No.：YN481615
CAS No. ：376640-41-4
规格
价格(RMB)
库存
| 产品名称: | BVT 2733 |
| CAS No.: | 376640-41-4 |
| Chemical Name: | 3-chloro-2-methyl-N-[4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-thiazolyl]-benzenesulfonamide |
| Synonyms: | BVT2733;3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide;3-chloro-2-methyl-N-[4-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1,3-thiazol-2-yl]benzenesulfonamide;BVT-2733;1-[[2-[[(3-Chloro-2-methylphenyl)sulfonyl]ami |
| 分子量: | 428.96 |
| 分子式: | C₁₇H₂₁ClN₄O₃S₂ |
| SMILES: | ClC1=C(C)C(S(NC2=NC(CC(N3CCN(C)CC3)=O)=CS2)(=O)=O)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BVT 2733 是一个强效的、选择性和具有口服活性的非甾体类11β-HSD1抑制剂。BVT 2733 对小鼠 11β-HSD1 酶的作用 (IC50=96 nM) 强于对人 11β-HSD1 酶 (IC50=3341 nM) 的。BVT 2733 具有研究关节炎和肥胖相关疾病的潜力。 |
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Alberts, P., Engblom, L., Edling, N., et al.Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic miceDiabetologia45(11),1528-1532(2002)
Wang, L., Liu, J., Zhang, A., et al.BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese micePLoS One7(7),e40056(2012)
Zhang, L., Dong, Y., Zou, F., et al.11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritisInt. Immunopharmacol.17(3),489-494(2013)
