Ro 48-8071
Cat. No.：YN481632
CAS No. ：161582-11-2
规格
价格(RMB)
库存
| 产品名称: | Ro 48-8071 |
| CAS No.: | 161582-11-2 |
| Chemical Name: | (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propenylamino)hexyl]oxy]phenyl]-methanone |
| Synonyms: | |
| 分子量: | 448.37 |
| 分子式: | C₂₃H₂₇BrFNO₂ |
| SMILES: | O=C(C1=CC=C(Br)C=C1)C2=CC=C(OCCCCCCN(C)CC=C)C=C2F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ro 48-8071 是氧化鲨烯环化酶 (Oxidosqualene cyclase) 抑制剂，IC50约为 6.5 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Vance, D.E.Cholesterol and related derivativesBiochemistry2nd ed.,725-748(1988)
Thoma, R., Schulz-Gasch, T., D'Arcy, B., et al.Insight into steroid scaffold formation from the structure of human oxidosqualene cyclaseNature432,118-122(2004)
Morand, O.H., Aebi, J.D., Dehmlow, H., et al.Ro 48-8071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: Comparison to simvastatinJ. Lipid Res.38,373-390(1997)
Shenoy, S.D., Spencer, T.A., Mercer-Haines, N.A., et al.Induction of CYP3A by 2,3-Oxidosqualene:Lanosterol cyclase inhibitors is mediated by an endogenouse squalene metabolite in primary cultured rat hepatocytesMol. Pharmacol.65,1302-1312(2004)
