Voxelotor
Cat. No.：YN481640
CAS No. ：1446321-46-5
规格
价格(RMB)
库存
| 产品名称: | Voxelotor |
| CAS No.: | 1446321-46-5 |
| Chemical Name: | 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-benzaldehyde |
| Synonyms: | GBT 440 |
| 分子量: | 337.37 |
| 分子式: | C₁₉H₁₉N₃O₃ |
| SMILES: | OC1=CC=CC(OCC2=C(C3=CC=NN3C(C)C)N=CC=C2)=C1C=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Voxelotor (GBT 440) 是一种有效的镰状血红蛋白 (HbS) 聚合抑制剂。Voxelotor 有潜力用于镰状细胞贫血病的研究。 |
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Oksenberg, D., Dufu, K., Patel, M.P., et al.GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell diseaseBr. J. Haematol.175(1),141-153(2016)
Dufu, K., Lehrer-Graiwer, J., Ramos, E., et al.GBT440 inhibits sickling of sickle cell trait blood under in vitro conditions mimicking strenuous exerciseHematol. Rep.8(3),6637(2016)
