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Coelenterazine

Cat. No.:YN481644

  • CAS No. :55779-48-1

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    • 参考文献
    • 产品名称: Coelenterazine
      CAS No.: 55779-48-1
      Chemical Name: 6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-imidazo[1,2-a]pyrazin-3(7H)-one
      Synonyms:腔肠素
      分子量:423.46
      分子式:C₂₆H₂₁N₃O₃
      SMILES:O=C1C(CC2=CC=C(O)C=C2)=NC3=C(CC4=CC=CC=C4)NC(C5=CC=C(O)C=C5)=CN31
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Coelenterazine 是 apoaequorin 和 Renilla 荧光素酶的发光酶底物。Renilla 荧光素酶和底物 coelenterazine 被用作生物发光共振能量转移 (BRET) 中检测蛋白质-蛋白质相互作用的生物发光供体。Coelenterazine 是一种超氧阴离子敏感化学发光探针,其也用于过氧亚硝酸盐的化学发光检测 。
      IC50和靶点:
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    • Sabnis, R.W.Handbook of biological dyes and stains: Synthesis and industrial applications,(2010)

      Pfleger, K.D., and Eidne, K.A.Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET)Nat. Methods3(3),165-174(2006)

      Dacres, H., Dumancic, M.M., Horne, I., et al.Direct comparison of bioluminescence-based resonance energy transfer methods for monitoring of proteolytic cleavageAnal. Biochem.385(2),194-202(2009)

      Stables, J., Green, A., Marshall, F., et al.A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptorAnal. Biochem.252(1),115-126(1997)

      Teranishi, K., and Shimomura, O.Coelenterazine analogs as chemiluminescent probe for superoxide anionAnal. Biochem.249(1),37-43(1997)

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