Kifunensine
Cat. No.：YN481664
CAS No. ：109944-15-2
规格
价格(RMB)
库存
| 产品名称: | Kifunensine |
| CAS No.: | 109944-15-2 |
| Chemical Name: | hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione |
| Synonyms: | FR-900494 |
| 分子量: | 232.19 |
| 分子式: | C₈H₁₂N₂O₆ |
| SMILES: | O=C(N1[C@@](N2)([H])[C@@H](O)[C@@H](O)[C@H](O)[C@H]1CO)C2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Kifunensine 是可从放线菌中分离得到的I 类 α-mannosidases有效选择性抑制剂，可阻断 α-mannosidases I 修剪糖蛋白上的甘露糖残基。Kifunensine 可抑制内质网相关蛋白降解途径。 |
| IC50和靶点: | |
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Iwami, M., Nakayama, O., Terano, H., et al.A new immunomodulator, FR-900494: Taxonomy, fermentation, isolation, and physico-chemical and biological characteristicsJ. Antibiot. (Tokyo)XL(5),612-622(1987)
Kayakiri, H., Takase, S., Shibata, T., et al.Structure of kifunensine, a new immunomodulator isolated from an actinomyceteJ. Org. Chem.54,4015-4016(1989)
Hering, K.W., Karaveg, K., Moremen, K.W., et al.A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-mannosidase IJ. Org. Chem.70,9892-9904(2005)
Bartoli, M., Gicquel, E., Barrault, L., et al.Mannosidase I inhibition rescues the human α-sarcoglycan R77C recurrent mutationHum. Mol. Genet.17(9),1214-1221(2008)
Soheili, T., Gicquel, E., Poupiot, J., et al.Rescue of sarcoglycan mutations by inhibition of endoplasmic reticulum quality control is associated with minimal structural modificationsHum. Mutat.33(2),429-439(2012)
