Seco Rapamycin sodium salt
Cat. No.：YN481676
CAS No. ：148554-65-8
规格
价格(RMB)
库存
| 产品名称: | Seco Rapamycin sodium salt |
| CAS No.: | 148554-65-8 |
| Chemical Name: | [2R-[2α,2(S*),3α,6β[2S*,3E,5E,7E,9S*,11R*,13R*,14R*,15E,7R*,19E,21R*,22(1S*,3R*,4R*)]]]-1-[oxo[tetrahydro-2-hydroxy-6-[14-hydroxy-22-(4-hydroxy-3methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaenyl]-3-methyl |
| Synonyms: | Seco雷帕霉素钠盐; Secorapamycin A monosodium |
| 分子量: | 936.15 |
| 分子式: | C₅₁H₇₈NNaO₁₃ |
| SMILES: | O=C([C@H]1N(C(C([C@@]2(O)[C@H](C)CC[C@@H](C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C([C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(/C=C/[C@H](C)C[C@H]3C[C@@H](OC)[C@H](O)CC3)=O)=O)O2)=O)=O)CCCC1)O[Na] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Seco Rapamycin sodium salt 是 Rapamycin 的开环代谢物。Seco-Rapamycin 几乎不影响 mTOR 功能。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Wang, C.P., Chan, K.W., Schiksnis, R.A., et al.High performance liquid chromatographic isolation, spectroscopic characterization, and immunosuppressive activities of two rapamycin degradation productsJ. Liq. Chromatogr.17(16),3383-3392(1994)
Paine, M.F., Leung, L.Y., Lim, H.K., et al.Identification of a novel route of extraction of sirolimus in human small intestine: Roles of metabolism and secretionJ. Pharmacol. Exp. Ther.301(1),174-186(2002)
Paine, M.F., Leung, L.Y., and Watkins, P.B.New insights into drug absorption: Studies with sirolimusTher. Drug Monit.26(5),463-467(2004)
Osmulski, P.A., and Gaczynska, M.Rapamycin allosterically inhibits the proteasomeMol. Pharmacol.84(1),104-113(2013)
