Rufinamide
Cat. No.：YN481748
CAS No. ：106308-44-5
规格
价格(RMB)
库存
| 产品名称: | Rufinamide |
| CAS No.: | 106308-44-5 |
| Chemical Name: | 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide |
| Synonyms: | 卢非酰胺; CGP 33101; E 2080; RUF 331 |
| 分子量: | 238.19 |
| 分子式: | C₁₀H₈F₂N₄O |
| SMILES: | O=C(C1=CN(CC2=C(F)C=CC=C2F)N=N1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rufinamide (E 2080; CGP 33101; RUF 331)是新型镇痫化合物，可用于 Lennox-Gastaut 综合症的的研究。 |
| IC50和靶点: | |
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Al-Banji, M.H., Zahr, D., and Jan, M.M.Lennox-Gastaut syndrome. Management updateNeuroscience (Riyadh)20(3),207-212(2015)
Wheless, J.W., and Vazquez, B.Rufinamide: A novel broad-spectrum antiepileptic drugEpilepsy Curr.10(1),1-6(2010)
Gilchrist, J.J., Dutton, S., Diaz-Bustamante, M., et al.Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodentsACS Chem. Biol.9(5),1204-1212(2014)
Costa, G., Carta, F., Ambrosio, F.A., et al.A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitorsEur. J. Med. Chem.181,111565(2019)
Gáll, Z., Orbán-Kis, K., and Szilágyi, T.Differential effects of sodium channel blockers on in vitro induced epileptiform activitiesArch. Pharm. Res.40(1),112-121(2017)
White, H.S., Franklin, M.R., Kupferberg, H.J., et al.The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure modelsEpilepsia49(7),1213-1220(2008)
Park, J.-A., and Lee, C.-H.Effect of Rufinamide on the kainic acid-induced excitotoxic neuronal death in the mouse hippocampusArch. Pharm. Res.41(7),776-783(2018)
