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Epoprostenol sodium

Cat. No.:YN481757

  • CAS No. :61849-14-7

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    • 产品名称: Epoprostenol sodium
      CAS No.: 61849-14-7
      Chemical Name: 6,9α-epoxy-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monosodium salt
      Synonyms:Prostaglandin I2 sodium salt; Prostacyclin sodium salt; Flolan
      分子量:374.45
      分子式:C₂₀H₃₁NaO₅
      SMILES:CCCCC[C@H](O)/C=C/[C@@H]1[C@H]([C@@]2([H])C[C@H]1O)C/C(O2)=C/CCCC(O[Na])=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Epoprostenol sodium (Prostaglandin I2 sodium salt) 是一种天然前列腺素衍生物前列环素 (prostaglandin I2) 的合成形式,用于肺动脉高压 (PAH) 的研究。Epoprostenol sodium 作为血小板聚集的有效抑制剂用于肺动脉高压和移植。
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    • Moncada, S., Gryglewski, R., Bunting, S., et al.An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregationNature263(5579),663-665(1976)

      Johnson, R.A., Morton, D.R., Kinner, J.H., et al.The chemical structure of prostaglandin X (prostacyclin)Prostaglandins12(6),915-928(1976)

      Stehle, R.G.Physical chemistry, stability, and handling of prostaglandins E2, F2α, D2 and I2: A critical summaryMethods Enzymol.86,436-459(1982)

      Aristoff, P.A., Johnson, P.D., and Harrison, A.W.Synthesis of 9-substituted carbacyclin analoguesJ. Org. Chem.48(26),5341-5348(1983)

      McLaughlin, V.V., Genthner, D.E., Panella, M.M., et al.Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertensionN. Engl. J. Med.338(5),273-277(1998)

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