Leflunomide
Cat. No.：YN481774
CAS No. ：75706-12-6
规格
价格(RMB)
库存
| 产品名称: | Leflunomide |
| CAS No.: | 75706-12-6 |
| Chemical Name: | 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide |
| Synonyms: | 来氟米特; HWA486; RS-34821; SU101 |
| 分子量: | 270.21 |
| 分子式: | C₁₂H₉F₃N₂O₂ |
| SMILES: | O=C(C1=C(C)ON=C1)NC2=CC=C(C(F)(F)F)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Leflunomide 是一种嘧啶合成抑制剂，通过抑制二氢乳清酸脱氢酶 (dihydroorotate dehydrogenase) 起作用，具有抗风湿的作用。 |
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Breedveld, F.C., and Dayer, J.-M.Leflunomide: Mode of action in the treatment of rheumatoid arthritisAnn. Rheum. Dis.59(11),841-849(2000)
Dimitrova, P., Skapenko, A., Herrmann, M.L., et al.Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiationJ. Immunol.169(6),3392-3399(2002)
Glant, T.T., Mikecz, K., Bartlett, R.R., et al.Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomideImmunopharmacology23(2),105-116(1992)
