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Penicillamine

Cat. No.:YN481797

  • CAS No. :52-67-5

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    • 产品名称: Penicillamine
      CAS No.: 52-67-5
      Chemical Name: 3-mercapto-D-valine
      Synonyms:青霉胺; D-(-)
      分子量:149.21
      分子式:C₅H₁₁NO₂S
      SMILES:N[C@H](C(C)(S)C)C(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Penicillamine (D-(-)-Penicillamine) 是 penicillin 的代谢降解产物,可作为螯合剂,作用于威尔逊氏病。
      IC50和靶点:
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    • Delangle, P., and Mintz, E.Chelation therapy in Wilson's disease: From D-penicillamine to the design of selective bioinspired intracellular Cu(I) chelatorsDalton Trans.41(21),6359-6370(2012)

      Abraham, E.P., Chain, E., Baker, W., et al.Penicillamine, a characteristic degradation product of penicillinNature151(3821),107(1943)

      Domingo, J.L., Gómez, M., and Jones, M.M.Comparative efficacy of several potential treatments for copper mobilization in copper-overloaded ratsBiol. Trace Elem. Res.74(2),127-139(2000)

      Klein, D., Lichtmannegger, J., Heinzmann, U., et al.Dissolution of copper-rich granules in hepatic lysosomes by D-penicillamine prevents the development of fulminant hepatitis in Long-Evans cinnamon ratsJ. Hepatol.32(2),193-201(2000)

      Rahimi, N., Sadeghzadeh, M., Javad-Paydar, M., et al.Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathwaysEpilepsy Behav.39,42-47(2014)

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