Bisacodyl
Cat. No.：YN481831
CAS No. ：603-50-9
规格
价格(RMB)
库存
| 产品名称: | Bisacodyl |
| CAS No.: | 603-50-9 |
| Chemical Name: | 4,4′-(2-pyridinylmethylene)bis-phenol, 1,1′-diacetate |
| Synonyms: | 比沙可啶 |
| 分子量: | 361.39 |
| 分子式: | C₂₂H₁₉NO₄ |
| SMILES: | CC(OC1=CC=C(C(C2=CC=C(OC(C)=O)C=C2)C3=NC=CC=C3)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bisacodyl 是一种刺激性缓泻剂，可直接作用于结肠以产生排便。Bisacodyl 通过直接激活结肠巨噬细胞来增加 PGE2的分泌。PGE2充当旁分泌因子并降低结肠中 AQP3 的表达，从而抑制水从腔向血管一侧的转移并导致通便作用。 |
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Jauch, R., Hankwitz, R., Beschke, K., et al.Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The common laxative principle of Bisacodyl and sodium picosulfateArzneimittelforschung25(11),1796-1800(1975)
Schreiner, J., Nell, G., and Loeschke, K.Effect of diphenolic laxatives on Na+-K+-activated ATPase and cyclic nucleotide content of rat colon mucosa in vivoNaunyn-Schmiedebergs Arch. Pharmacol.313(3),249-255(1980)
Ikarashi, N., Baba, K., Ushiki, T., et al.The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophagesAm. J. Physiol. Gastrointest. Liver Physiol.301(5),G887-G895(2011)
