Carglumic Acid
Cat. No.：YN481851
CAS No. ：1188-38-1
规格
价格(RMB)
库存
| 产品名称: | Carglumic Acid |
| CAS No.: | 1188-38-1 |
| Chemical Name: | N-(aminocarbonyl)-L-glutamic acid |
| Synonyms: | N-Carbamyl-L-glutamic acid |
| 分子量: | 190.15 |
| 分子式: | C₆H₁₀N₂O₅ |
| SMILES: | O=C(O)CC[C@@H](C(O)=O)NC(N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Carglumic acid (N-Carbamyl-L-glutamic acid) 是 N-乙酰谷氨酸 (NAG) 的功能类似物和氨甲酰磷酸合成酶 1(CPS1)的活化剂，用于研究与 N-乙酰谷氨酸合成酶 (NAGS) 缺陷相关的急性和慢性高氨血症。 |
| IC50和靶点: | |
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Häberle, J.Carglumic acid for the treatment of N-acetylglutamate synthase deficiency and acute hyperammonemiaExp. Rev. Endocrinol. Metab.7(3),263-271(2012)
Gauthier, N., Wu, J.W., Wang, S.P., et al.A liver-specific defect of Acyl-CoA degradation produces hyperammonemia, hypoglycemia and a distinct hepatic Acyl-CoA patternPLoS One8(7),e60581(2013)
Chen, C.-T., Chen, Y.-C., Yamaguchi, H., et al.Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivoAm. J. Cancer Res.5(12),3560-3569(2015)
