Dithranol
Cat. No.：YN481856
CAS No. ：1143-38-0
规格
价格(RMB)
库存
| 产品名称: | Dithranol |
| CAS No.: | 1143-38-0 |
| Chemical Name: | 1,8-dihydroxy-9(10H)-anthracenone |
| Synonyms: | 蒽林; Anthralin |
| 分子量: | 226.23 |
| 分子式: | C₁₄H₁₀O₃ |
| SMILES: | O=C1C2=C(C=CC=C2O)CC3=CC=CC(O)=C13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dithranol (Anthralin) 是一种蒽衍生物，损害 DNA 复制和减少细胞分裂。动物模型中，Dithranol 对银屑病斑块的愈合有效，可用于银屑病研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Holstein, J., Fehrenbacher, B., Brück, J., et al.Anthralin modulates the expression pattern of cytokeratins and antimicrobial peptides by psoriatic keratinocytesJ. Dermatol. Sci.87(3),236-245(2017)
McGill, A., Frank, A., Emmett, N., et al.The anti-psoriatic drug anthralin accumulates in keratinocyte mitochondria, dissipates mitochondrial membrane potential, and induces apoptosis through a pathway dependent on respiratory competent mitochondriaFASEB J.19(8),1012-1014(2005)
Schröder, J.M.Anthralin (1,8-dihydroxyanthrone) is a potent inhibitor of leukotriene production and LTB4-ω oxidation by human neutrophilsJ. Invest. Dermatol.87(5),624-629(1986)
Tang, L., Sundberg, J.P., Liu, H., et al.Old wine in new bottles: Reviving old therapies for alopecia areata using rodent modelsJ. Invest. Dermatol. Symp. Proc.8(2),212-216(2003)
