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Eflornithine hydrochloride hydrate

Cat. No.:YN481860

  • CAS No. :96020-91-6

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    • 产品名称: Eflornithine hydrochloride hydrate
      CAS No.: 96020-91-6
      Chemical Name: 2-(difluoromethyl)-ornithine, monohydrochloride, monohydrate
      Synonyms:DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate
      分子量:236.64
      分子式:C₆H₁₅ClF₂N₂O₃
      SMILES:NC(CCCN)(C(F)F)C(O)=O.[H]Cl.O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) 是酶鸟氨酸脱羧酶的特异性不可逆抑制剂。Eflornithine hydrochloride, hydrate 可用于非洲锥虫病和女性面部毛发过度生长的研究。
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    • Wallace, H.M., Fraser, A.V., and Hughes, A.A perspective of polyamine metabolismBiochem. J.376(Pt 1),1-14(2003)

      Takigawa, M., Enomoto, M., Nishida, Y., et al.Tumor angiogenesis and polyamines: α-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitroCancer Res.50(13),4131-4138(2014)

      Marton, L.J., Levin, V.A., Hervatin, S.J., et al.Potentiation of the antitumor therapeutic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea by α-difluoromethylornithine, an ornithine decarboxylase inhibitorCancer Res.41(11 Pt 1),4426-4431(1981)

      Hayes, C.S., Burns, M.R., and Gilmour, S.K.Polyamine blockade promotes antitumor immunityOncoimmunology3(1),e27360-27361-e27360-27363(2014)

      Yarlett, N., Waters, W.R., Harp, J.A., et al.Activities of DL-α-difluoromethylarginine and polyamine analogues against Cryptosporidium parvum infection in a T-cell receptor alpha-deficient mouse modelAntimicrob. Agents Chemother.51(4),1234-1239(2007)

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