Prazobind
Cat. No.：YN1730126
| 产品名称: | Prazobind |
| CAS No.: | 107021-36-3 |
| Chemical Name: | [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]bicyclo[2.2.2]octa-2,5-dien-2-yl-methanone |
| Synonyms: | SZL 49 |
| 分子量: | 421.5 |
| 分子式: | C23H27N5O3 |
| SMILES: | COC(C(OC)=C1)=CC2=C1C(N)=NC(N3CCN(C(C4=CC5C=CC4CC5)=O)CC3)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Prazobind (SZL 49) 是一种哌唑嗪类似物，是一种有效的α1肾上腺素受体阻滞剂。Prazobind 在富含 alpha 1A 肾上腺素受体 (海马区) 和 alpha 1B (肝) 亚型的组织中竞争具有类似效力 (IC50=1 nM) 的 alpha 1-肾上腺素受体结合位点。 |
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Helman, J., Kusiak, J.W., Pitha, J., et al.Inhibition of α1-adrenergic responsiveness in intact cells by a new, irreversible receptor antagonistBiochem. Bioph. Res. Commun.142(2),403-409(1987)
Mante, S., and Minneman, K.P.The alkylating prazosin analog SZL 49 inactivates both α1A- and α1B-adrenoceptorsEur. J. Pharmacol.208(2),113-117(1991)
Oriowo, M.α1‐adrenoceptor subtype(s) mediating noradrenaline‐induced contractions of the guinea‐pig aortaFundam. Clin. Pharmacol.8,214-219(1994)
