12-OxoETE
Cat. No.：YN1710037
| 产品名称: | 12-OxoETE |
| CAS No.: | 108437-64-5 |
| Chemical Name: | 12-oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid |
| Synonyms: | 12-KETE |
| 分子量: | 318.5 |
| 分子式: | C20H30O3 |
| SMILES: | CCCCC/C=C\CC(=O)/C=C\C=C\C/C=C\CCCC(=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 12-OxoETE 通过白三烯 B4 (LTB4) 受体或共同激活序列诱导胞质游离钙离子的快速、剂量依赖性增加。 |
| IC50和靶点: | |
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Falgueyret, J.P., Leblanc, Y., and Riendeau, D.Stereoselective carbonyl reductases from rat skin and leukocyte microsomes converting 12-ketoeicosatetraenoic acid to 12(S)-HETEFEBS Lett.262,197-200(1990)
Fruteau De Laclos, B., Maclouf, J., Poubelle, P., et al.Conversion of arachidonic acid into 12-oxo derivatives in human platelets. A pathway possibly involving the heme-catalysed transformation of 12-hydroperoxy-eicosatetraenoic acidProstaglandins33,315-337(1987)
Falgueyret, J.P., Leblanc, Y., Rokach, J., et al.NAD(P)H-dependent reduction of 12-ketoeicosatetraenoic acid to 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomesBiochem. Biophys. Res. Commun.156,1083-1089(1988)
Naccache, P.H., Leblanc, Y., Rokach, J., et al.Calcium mobilization and right-angle light scatter responses to 12-oxo-derivatives of arachidonic acid in neutrophils: Evidence for the involvement of the leukotriene B4 receptorBiochim. Biophys. Acta1133,102-106(1991)
