EXP3179
Cat. No.：YN1710039
CAS No. ：114798-36-6
| 产品名称: | EXP3179 |
| CAS No.: | 114798-36-6 |
| Chemical Name: | 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde |
| Synonyms: | Losartan Carboxaldehyde; DuP 167 |
| 分子量: | 420.9 |
| 分子式: | C22H21ClN6O |
| SMILES: | [H]N1N=NN=C1C2=CC=CC=C2C3=CC=C(CN4C(C([H])=O)=C(Cl)N=C4CCCC)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EXP3179 是氯沙坦重要的中间醛代谢产物。EXP3179 没有 AT1-R 阻断活性，但有效抑制内皮环氧合酶 (COX)-2 的表达。EXP3179 发挥有效的抗炎作用。 |
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R.A., S., Chakravarty, P.K., Chen, R., et al.Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily membersDrug Metab. Dispos.23(2),207-215(1995)
Krämer, C., Sunkomat, J., Witte, J., et al.Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: Role of the active metabolite EXP3179Circ. Res.90(7),770-776(2002)
Schupp, M., Lee, L.D., Frost, N., et al.Regulation of peroxisome proliferator-activated receptor γ activity by losartan metabolitesHypertension47(3),586-589(2006)
Fortuño, A., Bidegain, J., Robador, P.A., et al.Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: Potential clinical implications in hypertensionHypertension54(4),744-750(2009)
