Icosabutate
Cat. No.：YN1710040
CAS No. ：1253909-57-7
| 产品名称: | Icosabutate |
| CAS No.: | 1253909-57-7 |
| Chemical Name: | 2-[(5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaen-1-yloxy]-butanoic acid |
| Synonyms: | |
| 分子量: | 374.6 |
| 分子式: | C24H38O3 |
| SMILES: | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CC)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Icosabutate 是一种具有口服活性的 ω-3多不饱和脂肪酸，是二十碳五烯酸的衍生物 (EPA derivative)。Icosabutate 克服了未经修饰的 EPA 对肝脏靶向的缺点，可改善了胰岛素敏感性，肝炎和纤维化。Icosabutate 具有良好的耐受性，可有效降低持续性高甘油三酯血症中的非高密度脂蛋白胆固醇 (non-HDL-C) 水平。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bays, H.E., Hallèn, J., Vige, R., et al.Icosabutate for the treatment of very high triglycerides: A placebo-controlled, randomized, double-blind, 12-week clinical trialJ.Clin.Lipidol.10(1),181-191(2016)
Kastelein, J.J.P., Hallén, J., Vige, R., et al.Icosabutate, a structurally engineered fatty acid, improves the cardiovascular risk profile in statin-treated patients with residual hypertriglyceridemiaCardiology135(1),3-12(2016)
