B-355252
Cat. No.：YN1730131
| 产品名称: | B-355252 |
| CAS No.: | 1261576-81-1 |
| Chemical Name: | 4-chloro-N-(1-naphthalenylmethyl)-5-[3-(1-piperazinyl)phenoxy]-2-thiophenesulfonamide |
| Synonyms: | B355252; B 355252; B-355252. |
| 分子量: | 514.1 |
| 分子式: | C25H24ClN3O3S2 |
| SMILES: | O=S(NCC1=C2C(C=CC=C2)=CC=C1)(C3=CC(Cl)=C(OC4=CC=CC(N5CCNCC5)=C4)S3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | B355252 是一种苯氧基噻吩磺酰胺小分子，一种有效的NGF受体激动剂。B355252 增强 NGF 诱导的神经突生长。B355252 通过减轻 DNA 损伤、减少 ROS 产生和 LDH 水平以及防止神经元凋亡来保护缺血性神经元免受神经元损失。B355252 在谷氨酸诱导的兴奋性毒性以及帕金森病 (PD) 的小鼠海马细胞系 (HT22) 模型中具有抗凋亡作用。 |
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Williams, A., Dandepally, S.R., Gilyazova, N., et al.Microwave-assisted synthesis of 4-chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide (B-355252): A new potentiator of nerve growth factor (NGF)-induced neurite outgrowthTetrahedron66(50),9577-9581(2010)
Gliyazova, N.S., Huh, E.Y., and Ibeanu, G.A novel phenoxy thiophene sulphonamide molecule protects against glutamate evoked oxidative injury in a neuronal cell modelBMC Neurosci.14(93),1-13(2013)
Gliyazova, N.S., and Ibeanu, G.C.The chemical molecule B355252 is neuroprotective in an in vitro model of Parkinson's diseaseCell Mol. Neurobiol.36(7),1109-1122(2016)
