FR122047
Cat. No.：YN1710041
| 产品名称: | FR122047 |
| CAS No.: | 130717-51-0 |
| Chemical Name: | 1-[[4,5-bis(4-methoxyphenyl)-2-thiazolyl]carbonyl]-4-methyl-piperazine, monohydrochloride |
| Synonyms: | FR-122047; FR 122047; FR122047. |
| 分子量: | 459.98966 |
| 分子式: | C23H25N3O3S • HCl |
| SMILES: | O=C(N1CCN(C)CC1)C2=NC(C3=CC=C(OC)C=C3)=C(S2)C4=CC=C(OC)C=C4.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FR122047 (hydrochloride) 是一种选择性的口服活性COX-1抑制剂，其 IC50为 28 nM。FR122047(hydrochloride) 在体内具有抗血小板、镇痛和抗炎作用。 |
| IC50和靶点: | [{name:"COX-1:28 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ochi, T., Motoyama, Y., and Goto, T.The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive modelsEur. J. Pharmacol.391,49-54(2000)
Dohi, M., Sakata, Y., Seki, J., et al.The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitorEur. J. Pharmacol.243,179-184(1993)
Ochi, T., and Goto, T.Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritisBr. J. Pharmacol.135,782-788(2002)
