ML289
Cat. No.：YN1730132
CAS No. ：1382481-79-9
| 产品名称: | ML289 |
| CAS No.: | 1382481-79-9 |
| Chemical Name: | [3R-(hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone |
| Synonyms: | VU0463597 |
| 分子量: | 349.4 |
| 分子式: | C22H23NO3 |
| SMILES: | COC1=CC=C(C#CC2=CC=C(C(N3C[C@H](CO)CCC3)=O)C=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML289 (VU0463597) 是一种高效、选择性的，可透过血脑屏障的mGlu3(IC50=0.66 μM) 负变构调节剂。ML289 的选择性是 mGlu2 的 15 倍，对 mGlu5 无活性。 |
| IC50和靶点: | [{name:"mGluR3:0.66 μM (IC50)"}] |
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| Solvent & Solubility: |
Sheffler, D.J., Wenthur, C.J., Bruner, J.A., et al.Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAMBioorg. Med. Chem. Lett.22(12),3921-3925(2012)
