NGB 2904 hydrochloride
Cat. No.：YN1730140
| 产品名称: | NGB 2904 hydrochloride |
| CAS No.: | 189061-11-8 |
| Chemical Name: | N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide, monohydrochloride |
| Synonyms: | NGB 2904 hydrochloride |
| 分子量: | 530.9 |
| 分子式: | C28H29Cl2N3O • HCl |
| SMILES: | ClC1=C(Cl)C(N2CCN(CCCCN([H])C(C3=CC(CC4=C5C=CC=C4)=C5C=C3)=O)CC2)=CC=C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NGB 2904 hydrochloride 是一种有效，选择性，具有口服活性和可透过血脑屏障的多巴胺D3受体的拮抗剂，Ki值为 1.4 nM。NGB 2904 hydrochloride 对 D3 的选择性高于 D2，5-HT2，α1，D4，D1 和 D5 受体 (Ki=217，223，642，>5000，>10000 和 >10000 nM)。NGB 2904 hydrochloride 可拮抗 Quinpirole 刺激的有丝分裂。 |
| IC50和靶点: | [{name:"D3 Receptor:1.4 (Ki)"}] |
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Yuan, J., Chen, X., Brodbeck, R., et al.NGB 2904 and NGB 2849: Two highly selective dopamine D3 receptor antagonistsBioorg. Med. Chem. Lett.8(19),2715-2718(1998)
Grundt, P., Carlson, E.E., Cao, J., et al.Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptorJ. Med. Chem.48(3),839-848(2005)
Gilbert, J.G., Newman, A.H., Gardner, E.L., et al.Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: Role of dopamine D3 receptorsSynapse57(1),17-28(2005)
Xi, Z.-X., Newman, A.H., Gilbert, J.G., et al.The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in ratsNeuropsychopharmacology31(7),1393-1405(2006)
Pritchard, L.M., Newman, A.H., McNamara, R.K., et al.The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotionPharmacol. Biochem. Behav.86(4),718-726(2007)
