TCS PrP Inhibitor 13
Cat. No.：YN1590016
CAS No. ：34320-83-7
| 产品名称: | TCS PrP Inhibitor 13 |
| CAS No.: | 34320-83-7 |
| Chemical Name: | 2,4-dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one |
| Synonyms: | |
| 分子量: | 281.3 |
| 分子式: | C15H11N3O3 |
| SMILES: | O=C1CC(=NN1c1ccccc1)c1ccc(cc1)[N+](=O)[O-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TCS PrP Inhibitor 13作为一种抗朊病毒化合物，是一种细胞朊病毒蛋白(PrPC)抑制剂。TCS PrP Inhibitor 13作为朊病毒蛋白(PrP-res)积累抑制剂，在ScN2a和F3细胞株中均显示IC50值为3 nM。TCS PrP Inhibitor 13 诱导神经鞘瘤细胞调亡。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Prusiner, S.B.PrionsProc. Natl. Acad. Sci. USA95,13363-13383(1998)
Kimata, A., Nakagawa, H., Ohyama, R., et al.New series of antiprion compounds: Pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulationJ. Med. Chem.50,5053-5056(2007)
