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(-)-(E)-Guggulsterone

Cat. No.:YN1720063

  • CAS No. :39025-24-6

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    • 参考文献
    • 产品名称: (-)-(E)-Guggulsterone
      CAS No.: 39025-24-6
      Chemical Name: pregna-4-17(20)-diene-3,16-dione
      Synonyms:
      分子量:312.5
      分子式:C21H28O2
      SMILES:O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC(/C4=C\C)=O)=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: (-)-(E)-Guggulsterone 是 Z-guggulsterone 的代谢物。Guggulsterone 是 guggulipid 的活性成分,guggulipid 是一种源自 Commiphora mukul 的阿育吠陀活性分子。Guggulsterone 具有降血脂活性。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Makishima, M., Okamoto, A.Y., Repa, J.J., et al.Identification of a nuclear receptor for bile acidsScience284,1362-1365(1999)

      Barbier, O., Torra, I.P., Sirvent, A., et al.FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activityGastroenterology124,1926-1940(2003)

      Tan, K.P., Yang, M., and Ito, S.Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stressMol. Pharmacol.72(5),1380-1390(2007)

      Urizar, N.L., Liverman, A.B., Dodds, D.T., et al.A natural product that lowers cholesterol as an antagonist ligand for FXRScience296(5573),1703-1706(2002)

      Cui, J., Huang, L., Zhao, A., et al.Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pumpJ. Biol. Chem.278(12),10214-10220(2003)

      Wu, J., Xia, C., Meier, J., et al.The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptorMol. Endocrinol.16(7),1590-1597(2002)

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