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Glycolithocholic acid

Cat. No.:YN1710056

  • CAS No. :474-74-8

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    • 产品名称: Glycolithocholic acid
      CAS No.: 474-74-8
      Chemical Name: N-[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]-glycine
      Synonyms:Lithocholylglycine
      分子量:433.6
      分子式:C26H43NO4
      SMILES:C[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Glycolithocholic acid (Lithocholylglycine) 是一种内源性代谢产物,是一种甘氨酸结合的次级胆汁酸。Glycolithocholic acid 可用于诊断溃疡性结肠炎 (UC),非酒精性脂肪性肝炎 (NASH0) 和原发性硬化性胆管炎 (PSC)。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1),147-191(2009)

      Zhang, Y., and Klaassen, C.D.Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in miceJ. Lipid Res.51(11),3230-3242(2010)

      Cowan, E., Kimar, P., Burch, K.J., et al.Treatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomicsMetabolomics12(124),(2016)

      Semba, R.D., Gonzalez-Freier, M., Moaddel, R., et al.Environmental enteric dysfunction is associated with altered bile acid metabolismJ. Pediatr. Gastenterol. Nutr.64(4),536-540(2017)

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