G-5555
Cat. No.：YN290459
CAS No. ：1648863-90-4
| 产品名称: | G-5555 |
| CAS No.: | 1648863-90-4 |
| Chemical Name: | 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Synonyms: | G5555;G 5555 |
| 分子量: | 492.96 |
| 分子式: | C₂₅H₂₅ClN₆O₃ |
| SMILES: | ClC(C=C(C1=NC(C)=CC=C1)C=C2)=C2C3=CC4=CN=C(NC)N=C4N(C[C@@H]5OC[C@@H](N)CO5)C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | G-5555 是有效PAK1抑制剂，对 PAK1 和 PAK2 的Ki值分别为 3.7 nM 和 11 nM。 |
| IC50和靶点: | [{name:"PAK1:3.7 nM (Ki)"},{name: "PAK2:11 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ndubaku, C.O., Crawford, J.J., Drobnick, J., et al.Design of selective PAK1 inhibitor G-5555: Improving properties by employing an unorthodox low-pKa polar moietyACS Med. Chem. Lett.6(12),1241-1246(2015)
Braga, R.C., Alves, V.M., Silva, M.F., et al.Tuning HERG out: Antitarget QSAR models for drug developmentCurr. Top. Med. Chem.14(11),1399-1415(2014)
