Pamiparib
Cat. No.：YN290059
CAS No. ：1446261-44-4
| 产品名称: | Pamiparib |
| CAS No.: | 1446261-44-4 |
| Chemical Name: | (10aR)-2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one |
| Synonyms: | BGB-290 |
| 分子量: | 298.31 |
| 分子式: | C₁₆H₁₅FN₄O |
| SMILES: | O=C1NN=C2CN(CCC3)[C@@]3(C)C(N4)=C2C5=C4C=C(F)C=C51 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pamiparib (BGB-290) 是一种有效的，具有口服活性的高选择性PARP抑制剂，对PARP1和PARP2的IC50值分别为 0.9 nM 和 0.5 nM。Pamiparib 能透过血脑屏障，可用于包括实体瘤在内的多种肿瘤的研究。 |
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| Solvent & Solubility: |
Xiong, Y., Guo, Y., Liu, Y., et al.Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumorNeoplasia22(9),431-440(2020)
