AG14361
Cat. No.：YN290168
CAS No. ：328543-09-5
| 产品名称: | AG14361 |
| CAS No.: | 328543-09-5 |
| Chemical Name: | 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one |
| Synonyms: | AG-14361,AG 14361 |
| 分子量: | 320.39 |
| 分子式: | C₁₉H₂₀N₄O |
| SMILES: | O=C1NCCN2C3=C1C=CC=C3N=C2C4=CC=C(C=C4)CN(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AG14361 是一种有效的PARP-1抑制剂，Ki值 < 5 nM，在通透的 SW620 细胞和完整的 SW620 细胞中，抑制PARP-1的活性，IC50值分别为 29 nM 和 14 nM。 |
| IC50和靶点: | [{name:"PARP-1:0.5 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Skalitzky, D.J., Marakovits, J.T., Maegley, K.A., et al.Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitorsJ. Med. Chem.46(2),210-213(2003)
Calabrese, C.R., Almassy, R., Barton, S., et al.Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361J. Natl. Cancer Inst.96(1),56-67(2004)
Curtin, N.J., Wang, L.Z., Yiakouvaki, A., et al.Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cellsClin. Cancer Res.10(3),881-889(2004)
Smith, L.M., Willmore, E., Austin, C.A., et al.The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaksClin. Cancer Res.11(23),8449-8457(2005)
