RBN-2397
Cat. No.：YN290275
CAS No. ：2381037-82-5
| 产品名称: | RBN-2397 |
| CAS No.: | 2381037-82-5 |
| Chemical Name: | 5-[[(1S)-1-methyl-2-[3-oxo-3-[4-[5-(trifluoromethyl)-2-pyrimidinyl]-1-piperazinyl]propoxy]ethyl]amino]-4-(trifluoromethyl)-3(2H)-pyridazinone |
| Synonyms: | |
| 分子量: | 523.43 |
| 分子式: | C₂₀H₂₃F₆N₇O₃ |
| SMILES: | O=C1C(C(F)(F)F)=C(N[C@@H](C)COCCC(N2CCN(C3=NC=C(C(F)(F)F)C=N3)CC2)=O)C=NN1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RBN-2397 是一种强效的，跨物种的，且具有口服活性的 NAD+竞争性PARP7抑制剂，IC50值小于 3 nM。RBN-2397 有选择性地结合 PARP7 (Kd=0.001 μM) 并可以恢复干扰素 I 型信号转导。RBN-2397 有潜力用于研究晚期或转移性实体肿瘤。 |
| IC50和靶点: | [{name:"PARP-7:3 nM (IC50)"},{name: "PARP-7:1 nM (Kd)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Rasmussen, M., Tan, S., Somisetty, V.S., et al.PARP7 and Mono-ADP-Ribosylation negatively regulate estrogen receptor α signaling in human breast cancer cellsCells10,623(2021)
