PJ34 hydrochloride
Cat. No.：YN290283
CAS No. ：344458-15-7
| 产品名称: | PJ34 hydrochloride |
| CAS No.: | 344458-15-7 |
| Chemical Name: | N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-acetamide, monohydrochloride |
| Synonyms: | PJ34 HCl |
| 分子量: | 331.80 |
| 分子式: | C₁₇H₁₈ClN₃O₂ |
| SMILES: | O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PJ34 hydrochloride 是PARP1/2的抑制剂，IC50值分别为 110 nM 和 86 nM。 |
| IC50和靶点: | [{name:"PARP:110 nM (IC50)"},{name: "PARP-2:86 nM (IC50)"},{name: "PARP-1:110 nM (IC50)"}] |
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Radnai, B., Antus, C., Racz, B., et al.Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activationMol. Cancer11(34),(2012)
Kirby, C.A., Cheung, A., Fazal, A., et al.Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.68 (Pt 2),115-118(2012)
Nicolescu, A.C., Holt, A., Kandasamy, A.D., et al.Inhibition of matrix metalloproteinase-2 by PARP inhibitorsBiochem. Biophys. Res. Commun.387(4),646-650(2009)
