Talazoparib
Cat. No.：YN290382
CAS No. ：1207456-01-6
| 产品名称: | Talazoparib |
| CAS No.: | 1207456-01-6 |
| Chemical Name: | (8S,9R)-5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one |
| Synonyms: | 他拉唑帕利; BMN-673; LT-673 |
| 分子量: | 380.35 |
| 分子式: | C₁₉H₁₄F₂N₆O |
| SMILES: | O=C1NN=C2C3=C1C=C(F)C=C3N[C@H](C4=CC=C(F)C=C4)[C@H]2C5=NC=NN5C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Talazoparib (BMN-673) 是一种高效的，具有口服活性的PARP 1/2抑制剂。Talazoparib 抑制 PARP1 和 PARP2 酶活性的Ki值分别为 1.2 nM 和 0.87 nM。Talazoparib 具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"PARP2:0.87 nM (Ki)"},{name: "PARP1:1.2 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Shen, Y., Rehman, F.L., Feng, Y., et al.BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiencyClin. Cancer Res.19(18),5003-5015(2013)
