A-966492
Cat. No.：YN310076
| 产品名称: | A-966492 |
| CAS No.: | 934162-61-5 |
| Chemical Name: | 2-[2-fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-1H-benzimidazole-7-carboxamide |
| Synonyms: | 2-[2-氟-4-[(2S)-2-吡咯烷基]苯基]-1H-苯并咪唑-7-甲酰胺 |
| 分子量: | 324.35 |
| 分子式: | C₁₈H₁₇FN₄O |
| SMILES: | FC1=CC([C@H]2NCCC2)=CC=C1C3=NC4=C(C(N)=O)C=CC=C4N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-966492 是一种新颖的，有效的PARP1和PARP2抑制剂，Ki值为 1 nM 和 1.5 nM。 |
| IC50和靶点: | [{name:"PARP-1:1 nM (Ki)"},{name: "PARP-2:1.5 nM (Ki)"}] |
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Penning, T.D., Zhu, G.D., Gong, J., et al.Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: Identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitorJ. Med. Chem.53(8),3142-3153(2010)
