AZ6102
Cat. No.：YN310204
CAS No. ：1645286-75-4
| 产品名称: | AZ6102 |
| CAS No.: | 1645286-75-4 |
| Chemical Name: | rel-2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one |
| Synonyms: | AZ-6102 |
| 分子量: | 428.53 |
| 分子式: | C₂₅H₂₈N₆O |
| SMILES: | O=C1C2=C(N(C)C=C2)N=C(C3=CC=C(C4=C(C)C=C(N5C[C@@H](C)N[C@@H](C)C5)N=C4)C=C3)N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZ6102 是一种有效的TNKS1和TNKS2双重抑制剂，IC50值分别为 3 nM 和 1 nM，选择性是对 PARP 家族其他蛋白的 100 多倍，对 PARP1，PARP2 和 PARP6 的IC50值分别为 2.0 μM，0.5 μM 和 >3 μM。 |
| IC50和靶点: | [{name:"TNKS2:2 nM (IC50)"},{name: "TNKS1:3 nM (IC50)"},{name: "PARP1:2 μM (IC50)"},{name: "PARP2:0.5 μM (IC50)"}] |
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| Solvent & Solubility: |
Johannes, J.W., Almeida, L., Barlaam, B., et al.Pyrimidinone nicotinamide mimetics as selective tankyrase and Wnt pathways inhibitors suitable for in vivo pharmacologyACS Med. Chem. Lett.6,254-259(2015)
