UPF 1069
Cat. No.：YN310256
CAS No. ：1048371-03-4
| 产品名称: | UPF 1069 |
| CAS No.: | 1048371-03-4 |
| Chemical Name: | 5-(2-oxo-2-phenylethoxy)-1(2H)-isoquinolinone |
| Synonyms: | UPF1069; UPF1069 |
| 分子量: | 279.29 |
| 分子式: | C₁₇H₁₃NO₃ |
| SMILES: | O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UPF 1069 是一种PARP抑制剂，对 PARP-1 和 PARP-2 的IC50值分别为 8 和 0.3 μM。 |
| IC50和靶点: | [{name:"PARP-2:0.3 μM (IC50)"},{name: "PARP-1:8 μM (IC50)"}] |
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| Solvent & Solubility: |
Pellicciari, R., Camaioni, E., Costantino, G., et al.On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivativesChem. Med. Chem.3(6),914-923(2008)
Moroni, F., Formentini, L., Gerace, E., et al.Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damageBrit. J. Pharmacol.157(5),854-862(2009)
