NU1025
Cat. No.：YN310257
CAS No. ：90417-38-2
| 产品名称: | NU1025 |
| CAS No.: | 90417-38-2 |
| Chemical Name: | 8-hydroxy-2-methyl-4(3H)-quinazolinone |
| Synonyms: | NSC 696807 |
| 分子量: | 176.17 |
| 分子式: | C₉H₈N₂O₂ |
| SMILES: | OC1=C(N=C(C)NC2=O)C2=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NU1025 是一种有效的PARP抑制剂，IC50为 400 nM，Ki为 48 nM。NU1025 可增强电离辐射和抗癌药物的细胞毒性，并具有抗癌和神经保护的作用。 |
| IC50和靶点: | |
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Griffin, R.J., Srinivasan, S., Bowman, K., et al.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)J. Med. Chem.41(26),5247-5256(1998)
Bowman, K.J., White, A., Golding, B.T., et al.Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064Br. J. Cancer78(10),1269-1277(1998)
Delaney, C.A., Wang, L.Z., Kyle, S., et al.Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell linesClin. Cancer Res.6(7),2860-2867(2000)
Kumala, S., Fujarewicz, K., Jayaraju, D., et al.Repair of DNA strand breaks in a minichromosome in vivo: Kinetics, modeling, and effects of inhibitorsPLoS One8(1),(2013)
