MN-64
Cat. No.：YN310321
CAS No. ：92831-11-3
| 产品名称: | MN-64 |
| CAS No.: | 92831-11-3 |
| Chemical Name: | 2-[4-(1-methylethyl)phenyl]-4H-1-benzopyran-4-one |
| Synonyms: | MN64 |
| 分子量: | 264.32 |
| 分子式: | C₁₈H₁₆O₂ |
| SMILES: | O=C1C=C(C2=CC=C(C(C)C)C=C2)OC3=CC=CC=C13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MN-64 是一种有效的tankyrase 1抑制剂，对TNKS1, TNKS2, ARTD1 and ARTD2 的IC50值分别为 6 nM，72 nM，19.1 μM 和 39.4 μM。 |
| IC50和靶点: | [{name:"TNKS1:6 nM (IC50)"},{name: "TNKS2:72 nM (IC50)"},{name: "ARTD1:19.1 μM (IC50)"},{name: "ARTD2:39.4 μM (IC50)"}] |
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Narwal, M., Koivunen, J., Haikarainen, T., et al.Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivityJ. Med. Chem.56(20),7880-7889(2013)
Haikarainen, T., Krauss, S., and Lehtiö, L.Tankyrases: Structure, function, and therapeutic implications in cancerCurr. Pharm. Des.20,6472-6488(2014)
