1,5-Isoquinolinediol
Cat. No.：YN310382
| 产品名称: | 1,5-Isoquinolinediol |
| CAS No.: | 5154-02-9 |
| Chemical Name: | 5-hydroxy-1(2H)-isoquinolinone |
| Synonyms: | |
| 分子量: | 161.16 |
| 分子式: | C₉H₇NO₂ |
| SMILES: | O=C1NC=CC2=C1C=CC=C2O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 1,5-Isoquinolinediol 是一种 有效的PARP抑制剂，IC50值为 0.18-0.37 µM。1,5-Isoquinolinediol 减轻糖尿病诱导的视网膜 NADPH 氧化酶诱导的氧化应激。 |
| IC50和靶点: | [{name:"PARP:0.18-0.37 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Davar, D., Beumer, J.H., Hamieh, L., et al.Role of PARP inhibitors in cancer biology and therapyCurr. Med. Chem.19(23),3907-3921(2012)
Banasik, M., Komura, H., Shimoyama, M., et al.Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferaseJ. Biol. Chem.267(3),1569-1575(1992)
Ruscetti, T., Lehnert, B.E., Halbrook, J., et al.Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymeraseJ. Biol. Chem.273(23),14461-14467(1998)
Chatterjee, P.K., Zacharowski, K., Cuzzocrea, S., et al.Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivoFASEB J.14(5),641-651(2000)
Bowes, J., McDonald, M.C., Piper, J., et al.Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stressCardiovasc. Res.41(1),126-134(1999)
Byun, J.Y., Kim, M.J., Eum, D.Y., et al.Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cellsMol. Pharmacol.76(4),734-744(2009)
Kang, Y.H., Yi, M.J., Kim, M.J., et al.Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: Reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondriaCancer Res.64(24),8960-8967(2004)
