SU4312
Cat. No.：YN440009
CAS No. ：5812-07-7
规格
价格(RMB)
库存
| 产品名称: | SU4312 |
| CAS No.: | 5812-07-7 |
| Chemical Name: | 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one |
| Synonyms: | NSC 86429,SU 4312 |
| 分子量: | 264.32 |
| 分子式: | C₁₇H₁₆N₂O |
| SMILES: | O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N(C)C)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SU4312 是 (Z)-SU4312 和 (E)-SU4312 的外消旋体。(Z)-SU4312 抑制 PDGFR 和 FLK-1，IC50分别为 19.4 和 0.8 μM。(E)-SU4312 抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R，IC50分别为 24.2，5.2，18.5，16.9 和 10.0 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Sun, L., Tran, N., Tang, F., et al.Synthesis and biological evaluations of 3-substituted indolin-2-ones: A novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinasesJ. Med. Chem.41(14),2588-2603(1998)
Tran, T.C., Sneed, B., Haider, J., et al.Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafishCancer Res.67(23),11386-11392(2007)
Cui, W., Zhang, Z., Li, W., et al.The anti-cancer agent SU4312 unexpectedly protects against MPP+ -induced neurotoxicity via selective and direct inhibition of neuronal NOSBr. J. Pharmacol.168(5),1201-1214(2013)
