Sunitinib Malate
Cat. No.：YN440070
CAS No. ：341031-54-7
规格
价格(RMB)
库存
| 产品名称: | Sunitinib Malate |
| CAS No.: | 341031-54-7 |
| Chemical Name: | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, (2S)-hydroxy-butanedioic acid |
| Synonyms: | SU 11248 Malate |
| 分子量: | 532.56 |
| 分子式: | C₂₆H₃₃FN₄O₇ |
| SMILES: | O=C(NCCN(CC)CC)C1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)F)=O)=C1C)C.O=C([C@H](CC(O)=O)O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sunitinib Malate (SU 11248 Malate) 是一种多靶点受体酪氨酸激酶抑制剂，抑制VEGFR2和PDGFRβ的IC50分别为80 nM 和 2 nM。Sunitinib Malate 是ATP 竞争性抑制剂，可通过抑制自身磷酸化和随后的 RNase 激活来有效抑制Ire1α的磷酸化。 |
| IC50和靶点: | [{name:"VEGFR2:80 nM (IC50)"},{name: "PDGFRβ:2 nM (IC50)"}] |
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O'Farrell, A.M., Abrams, T.J., Yuen, H.A., et al.SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivoBlood101(9),3597-3605(2003)
Mendel, D.B., Laird, A.D., Xin, X., et al.In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationshipClin. Cancer Res.9(1),327-337(2003)
